In Common Variable Immunodeficiency (CVID), what is the risk associated with the condition?

Common Variable Immunodeficiency (CVID) is characterized by a significant defect in the immune system leading to an inability to produce adequate antibodies. While individuals with CVID are indeed at an increased risk of infections due to their impaired immune response, the risk extends beyond just infections. These patients also have a notably elevated risk of malignant conditions such as lymphomas and autoimmune diseases, making them susceptible to both cancer and conditions where the immune system mistakenly attacks the body's own tissues.

The link between CVID and both malignancies and autoimmune disorders arises from the dysregulation of immune function. The underlying issues with antibody production and the accompanying abnormal immune responses can pave the way for the development of these additional serious health problems. Thus, the risk profile for someone with CVID is multifaceted, including both infections and other significant complications, reinforcing the importance of holistic management of the condition.

Other options do not capture the full spectrum of risks associated with CVID. While infections are a major concern, they do not encompass the complete risk landscape. Progressive neurological decline and the development of asthma are not directly tied to CVID, making these points less critical in understanding the risks associated with this immunodeficiency disorder.