Neuroblastoma typically arises from which type of cells?

Neuroblastoma typically arises from neural crest cells, which are a group of cells that develop from the embryonic ectoderm. These cells migrate during embryonic development to form various structures, including parts of the peripheral nervous system and certain endocrine tissues. In the case of neuroblastoma, the tumor originates specifically from neuroblasts—immature nerve cells that can differentiate into sympathetic neurons and adrenal medullary cells.

Neuroblastoma is most common in infants and young children and often presents in areas where sympathetic ganglia are found, such as the adrenal glands and along the sympathetic chain. Understanding the origin of this tumor is critical for diagnosis and treatment, as it reflects the developmental pathway of the neuroblast cells involved.

Other answer choices are not applicable because hematopoietic progenitor cells are responsible for the formation of blood cells, mesodermal cells contribute to structures like muscles and bones, and epithelial cells form surfaces and linings throughout the body. Thus, while all these cell types are important in various contexts, only neural crest cells specifically give rise to neuroblastoma.