What are specific findings highly suggestive of congenital syphilis, besides jaundice and hepatosplenomegaly?

Congenital syphilis can present with a variety of clinical findings that help in its diagnosis. Besides jaundice and hepatosplenomegaly, copious rhinorrhea and a maculopapular rash are highly suggestive of congenital syphilis.

In affected infants, the nasal discharge (rhinorrhea) can be quite profuse, often described as a "snuffles" type of presentation, which is due to the inflammation and irritation of the nasal mucosa caused by the Treponema pallidum infection. The maculopapular rash typically appears on the infant’s body, including the trunk and extremities, and can be widespread. This rash is part of the skin manifestations associated with syphilis, distinguishing it from other conditions.

Other findings associated with congenital syphilis may include bone abnormalities, such as periostitis, and hematological findings. The diagnosis can be bolstered through maternal testing, infant serology, and clinical presentation in the context of maternal syphilis history.

In this case, chorioamnionitis and preterm labor, cleft lip and palate, and clubbing and cyanosis do not specifically indicate congenital syphilis. Chorioamnionitis and pre