What are the three classic features of McCune-Albright syndrome?

The three classic features of McCune-Albright syndrome are precocious puberty, café au lait spots, and polyostotic fibrous dysplasia.

In this syndrome, café au lait spots are characterized by their light brown pigmentation and irregular borders, which can be a significant dermatological finding. Polyostotic fibrous dysplasia involves the replacement of bone tissue with fibrous tissue, leading to deformities and potential fractures, as affected bones are more fragile. Additionally, precocious puberty occurs due to hormonal imbalances associated with the condition, particularly involving the activation of the endocrine system earlier than expected.

These components are central to the diagnosis of McCune-Albright syndrome and help differentiate it from other conditions that might present with similar features. Each of these characteristics plays an important role in the clinical management and understanding of this genetic disorder.