What characterizes the maculopapular rash associated with congenital syphilis?

The maculopapular rash associated with congenital syphilis is characterized by its potential to desquamate or become bullous. This rash typically presents in neonates infected with Treponema pallidum and can manifest in a variety of ways. In many cases, it starts as a maculopapular eruption that can progress to involve desquamation, leading to peeling of the skin. Additionally, in some instances, the rash can develop bullae, which are fluid-filled blisters. This variability in presentation is significant as it reflects the diverse and sometimes severe effects of congenital syphilis on skin and overall health in infants.

The other options do not accurately describe the rash associated with congenital syphilis. The rash is not limited to just the face, indicating that it can occur on other parts of the body. Moreover, while some rashes may not desquamate, the hallmark of congenital syphilis is the tendency to desquamate or form bullae. Lastly, although some rashes can be pruritic, the rash of congenital syphilis is generally not described as being particularly itchy or irritating, differentiating it from other conditions where pruritus is a primary symptom.