What condition is associated with the presence of nephrotic syndrome?

Nephrotic syndrome is characterized by a specific set of clinical findings, including significant proteinuria, hypoalbuminemia, hyperlipidemia, and edema. Among these findings, periorbital edema is particularly common due to fluid accumulation, which occurs as a result of low serum albumin levels that decrease oncotic pressure. This condition can lead to generalized edema, including swelling around the eyes, which may be more noticeable in the morning.

Fatigue can also accompany nephrotic syndrome due to various factors, including the underlying kidney disease process, loss of proteins that contribute to overall health, and the effects of edema. The presence of edema and fatigue makes this answer the most closely aligned with the common symptoms seen in patients with nephrotic syndrome.

In contrast, other choices, such as nocturnal enuresis, hypoglycemia, and respiratory distress, are not typically associated with nephrotic syndrome. Nocturnal enuresis primarily relates to urinary issues, hypoglycemia is related to glucose metabolism, and respiratory distress pertains to the respiratory system rather than kidney function or fluid balance. The relationship between nephrotic syndrome and the symptoms of fatigue and periorbital edema clearly highlights why this option is correct.