What condition results in upper respiratory infections, poor wound healing, and skin infections?

The condition that results in upper respiratory infections, poor wound healing, and skin infections is best attributed to leukocyte adhesion deficiency (LAD). This disorder is characterized by a defect in the adhesion molecules on leukocytes, which impairs their ability to migrate to sites of infection and inflammation.

As a result, individuals with LAD experience recurrent bacterial infections, particularly in the skin and mucosal areas, since neutrophils, which are crucial for fighting infections, cannot effectively reach the infection sites. This leads to inadequate responses to infections, making affected individuals more susceptible to upper respiratory infections and skin infections. Additionally, the impaired traffic of leukocytes prevents effective wound healing, contributing to persistent or non-healing wounds.

In contrast, the other conditions listed have different underlying mechanisms and clinical presentations. Wiskott-Aldrich syndrome is characterized by an immunodeficiency associated with eczema and thrombocytopenia. Bruton Agammaglobulinemia primarily results in a deficiency of antibodies leading to an increased risk of infections, particularly viral and bacterial infections, rather than issues with healing. Chronic Granulomatous Disease is characterized by the inability of phagocytes to kill certain types of bacteria but does not specifically lead to poor wound healing as seen in LAD.