What is the diagnosis for a newborn with jaundice, clear rhinorrhea, maculopapular rash, and hepatosplenomegaly?

In this scenario, the clinical presentation of jaundice, clear rhinorrhea, maculopapular rash, and hepatosplenomegaly is most indicative of congenital rubella syndrome.

Congenital rubella syndrome is characterized by a distinct set of anomalies that may include cardiac defects, hearing impairment, cataracts, and characteristic rash, often accompanied by signs of infection such as jaundice and hepatosplenomegaly. The presence of clear rhinorrhea also aligns with viral infections and is commonly noted in congenital rubella, wherein the mother acquires rubella during pregnancy.

While congenital syphilis can present with some similar findings, such as jaundice and rash, the pattern of symptoms here and the clear rhinorrhea are more strongly associated with rubella. Neonatal herpes typically presents with vesicular lesions and signs of severe systemic infection rather than a maculopapular rash. Hereditary spherocytosis would lead to anemia and splenomegaly but would not cause the accompanying respiratory signs or rash. Thus, the combination of symptoms presented fits best with a diagnosis of congenital rubella syndrome.