What is the diagnosis for a term male infant with overlapping fingers, microcephaly, and rocker-bottom feet?

The presentation of overlapping fingers, microcephaly, and rocker-bottom feet in a term male infant is indicative of Edwards syndrome, also known as trisomy 18. This condition is characterized by a range of physical abnormalities that can be identified at birth.

Overlapping fingers, where the fingers are positioned such that one overlaps the other, is a notable feature seen in this syndrome. Microcephaly, or a reduced head size compared to normal, is another common finding in infants with Edwards syndrome. Lastly, rocker-bottom feet, which show a rounded appearance where the sole of the foot curves outward and the heel is prominent, is a classic physical characteristic linked to this condition.

These features help differentiate Edwards syndrome from other genetic conditions. In contrast, Down syndrome is associated with distinct facial features and a different set of congenital anomalies, while Patau syndrome presents with a triad of polydactyly, midline defects, and severe developmental delays. Turner syndrome primarily affects females and is characterized by short stature and absence of menstruation, making it less relevant in the context of a male infant with these specific features.

Therefore, based on the combination of overlapping fingers, microcephaly, and rocker-bottom feet, the diagnosis of Edwards syndrome is