What is the most likely diagnosis for a 3-year-old African American male presenting with sudden onset of difficulty walking and clumsiness of the right hand?

The sudden onset of difficulty walking and clumsiness of the right hand in this 3-year-old boy raises strong concerns for a neurological event, with stroke being the most likely diagnosis. Stroke in children, although less common than in adults, can occur due to several factors, such as sickle cell disease, which is particularly prevalent among African American populations.

In this case, the acute symptoms presenting in a young child suggest a focal neurological deficit, which is characteristic of a stroke. These deficits can manifest as sudden weakness, coordination issues, or changes in motor skills, aligning with the child's difficulty walking and clumsiness with the hand.

Early recognition of stroke in children is crucial, as prompt medical attention can significantly affect outcomes. Other conditions like transient synovitis, cerebral palsy, or multiple sclerosis do not typically present with such an acute change in function or with the rapid onset observed here. Transient synovitis generally presents with hip pain and limping but does not lead to clumsiness of the hand. Cerebral palsy is usually associated with developmental delays rather than sudden changes. Multiple sclerosis is also uncommon in such a young child and typically presents with a different symptom profile over a longer duration of time.

Thus, given