Which hormone fluctuations are linked to the tenderness associated with fibroadenomas?

The tenderness associated with fibroadenomas is primarily linked to fluctuations in estrogen and progesterone levels. Fibroadenomas are benign breast tumors that can be influenced by hormonal changes, particularly those occurring during the menstrual cycle.

Estrogen promotes epithelial proliferation in breast tissue, contributing to the growth of fibroadenomas. Additionally, progesterone can cause changes in breast tissue that may lead to sensitivity and tenderness. These hormones fluctuate with the menstrual cycle, and women may notice increased tenderness or swelling in their breasts in the days leading up to menstruation when progesterone levels are elevated.

Understanding the role of estrogen and progesterone in breast tissue dynamics helps explain why some women experience tenderness in connection to fibroadenomas, particularly during specific phases of their cycle. This hormonal interplay is key in benign breast conditions, distinguishing them from others that may not be influenced by these hormones in the same way.