Which syndrome is characterized by coarse facies, abscesses, and hyper-IgE?

The syndrome characterized by coarse facies, abscesses, and elevated levels of immunoglobulin E (hyper-IgE) is Job syndrome, also known as Hyper-IgE syndrome. This condition is primarily due to a defect in the immune system that results in a vulnerability to various infections, particularly staphylococcal abscesses, and also presents with characteristic facial features, including a coarse appearance.

Individuals with Job syndrome often have recurrent skin infections and respiratory tract infections. The high levels of IgE are notable and lead to an increased susceptibility to allergies as well as certain types of infections, particularly those caused by bacteria and fungi. The presence of coarse facial features can include broad nasal bridge, prominent forehead, and other distinct traits that help clinicians in making a diagnosis.

Understanding these features and their association with the underlying immune dysfunction is essential in pediatric practice, as it aids in early identification and appropriate management of infections in affected children.