Which syndrome is commonly associated with Wilms' tumor?

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Wilms' tumor, a type of kidney cancer that primarily affects children, is notably associated with Beckwith-Wiedemann syndrome. This syndrome is characterized by a variety of symptoms, including overgrowth, abdominal wall defects, and an increased risk of certain tumors, particularly Wilms' tumor and hepatoblastoma.

The association is particularly significant because children with Beckwith-Wiedemann syndrome have a genetic predisposition to developing Wilms' tumor due to abnormalities in genomic imprinting on chromosome 11. This chromosome is crucial for growth regulation and can lead to excessive cell proliferation and tumor development when disrupted.

In contrast, while Turner syndrome, Down syndrome, and Marfan syndrome are associated with their own set of health issues and complications, they do not have a recognized or strong correlation with Wilms' tumor in the same way that Beckwith-Wiedemann syndrome does. Therefore, Beckwith-Wiedemann syndrome is specifically highlighted for its connection to the development of Wilms' tumor, making it the correct answer in this context.

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